Lines around the mouth and nose are a sign of the normal aging process as a result of losing collagen, hyaluronic acid, and elastin in the skin. The skin tissues lose their firmness resulting in wrinkles and a sagging face with no volume. Radiesse and Belotero are dermal fillers that are FDA-approved to smooth moderate to severe facial wrinkles and folds. Although not used to treat the same wrinkle or fold at the same time, each can provide immediate correction for natural-looking results.